Umbrella Review on ACEs
An umbrella review of systematic reviews and meta-analyses was undertaken to better understand the association between adverse childhood experiences (ACEs) and common mental disorders and suicidality. This review aimed to identify the key ACEs that contribute to common mental disorders and suicidality.
We included 68 reviews with moderate (55%), low (28%) or critically low (17%) methodological quality. The median number of included studies in these reviews was 14 (2-277). Across identified reviews, 24 ACEs were associated with increased risk of common mental disorders or suicidality. ACEs were associated with a two-fold higher odds of anxiety disorders (pooled odds ratios (ORs): 1.94; 95% CI: 1.82, 2.22; I2 = 83.1%), internalizing disorders (OR: 1.76; 1.59, 1.87; I2= 74.2%), depression (OR: 2.01; 1.86, 2.32; I2 = 83.4%) and suicidality (OR: 2.33; 2.11, 2.56; I2= 88.6%). These associations did not significantly (P>0.05) vary by gender or the age of exposure.
We found that ACEs are consistently associated with increased risk of common mental disorders and suicidality. Well-designed cohort studies to track the impact of ACEs, and trials of interventions to prevent them or reduce their impact should be global research priorities read more...